| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHOX2B |
| Gene ID: | 8929 |
| Uniprot ID: | PHX2B_HUMAN |
| Immunogen Region: | 1-90 |
| Immunogen Sequence: | MYKMEYSYLNSSAYESCMAG MDTSSLASAYADFSSCSQAS GFQYNPIRTTFGATSGCPSL TPGSCSLGTLRDHQSSPYAA VPYKLFTDHG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PHOX2B (NP_003915.2). |
| Tissue Specificity | Expressed in neuroblastoma, brain and adrenal gland. |
| Function | Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. |
| Protein Name | Paired Mesoderm Homeobox Protein 2bNeuroblastoma PhoxNbphoxPhox2b Homeodomain ProteinPaired-Like Homeobox 2b |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 2b antibodyAnti-Neuroblastoma Phox antibodyAnti-Nbphox antibodyAnti-Phox2b Homeodomain Protein antibodyAnti-Paired-Like Homeobox 2b antibodyAnti-PHOX2B antibodyAnti-PMX2B antibody |
Information sourced from Uniprot.org
