Anti-Phosphohistone H3 antibody [IHC648] (STJA0042246)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
General Information
| Short Description | Mouse monoclonal anti-Phosphohistone H3 for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC648 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Specificity | Tested and validated on tonsil tissue. |
Additional Info
| Background | Phosphohistone H3 (PHH3) is a histone protein involved in forming the major protein structure of chromatin in eukaryotic cells. Anti-Phosphohistone H3 (PHH3) has been shown to be specific for the core protein histone H3 only when phosphorylated at serine 10 or serine 28, deeming PHH3 useful as a mitotic marker for differentiating mitotic figures from apoptotic bodies and karyorrhectic debris, since phosphorylation on histone H3 is not detected during apoptosis. Phosphohistone H3 may therefore be useful in diagnosis of tumour grades, especially in central nervous system, skin, gynecological, soft tissue, and gastrointestinal stromal tumours. Immunohistochemical staining with Anti-PHH3 has also been considered highly useful in prognosis of breast cancer, melanoma, and meningiomas. |
Information sourced from Uniprot.org