| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-DNA repair protein XRCC1-Thr284 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XRCC1 |
| Gene ID: |
7515 |
| Uniprot ID: |
XRCC1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human XRCC1 (Phospho-Thr284) |
| Tissue Specificity | Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level). |
| Post Translational Modifications | Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. Sumoylated. |
| Function | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity. |
| Protein Name | Dna Repair Protein Xrcc1X-Ray Repair Cross-Complementing Protein 1 |
| Database Links | Reactome: R-HSA-110381Reactome: R-HSA-5649702Reactome: R-HSA-5685939Reactome: R-HSA-5696397Reactome: R-HSA-6782210 |
| Cellular Localisation | NucleusChromosomeMoves From The Nucleoli To The Global Nuclear Chromatin Upon Dna DamageRecruited To Dna Damage Sites Fowwing Interaction With Poly-Adp-Ribose Chains |
| Alternative Antibody Names | Anti-Dna Repair Protein Xrcc1 antibodyAnti-X-Ray Repair Cross-Complementing Protein 1 antibodyAnti-XRCC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
