| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VAV1 |
| Gene ID: | 7409 |
| Uniprot ID: | VAV_HUMAN |
| Specificity: | A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1 |
| Tissue Specificity | Widely expressed in hematopoietic cells but not in other cell types. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN. |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Protein Name | Proto-Oncogene Vav |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-193648Reactome: R-HSA-2029482Reactome: R-HSA-2219530Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-389359Reactome: R-HSA-416482Reactome: R-HSA-4420097Reactome: R-HSA-512988Reactome: R-HSA-5218920Reactome: R-HSA-6811558Reactome: R-HSA-8980692Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9027284Reactome: R-HSA-912631Reactome: R-HSA-9664422Reactome: R-HSA-9679191Reactome: R-HSA-9748787Reactome: R-HSA-983695 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Proto-Oncogene Vav antibodyAnti-VAV1 antibodyAnti-VAV antibody |
Information sourced from Uniprot.org
