Anti-Phospho-TRAF2-Ser11 antibody (STJ196458)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human TRAF2 (Ser11)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-TNF receptor-associated factor 2-Ser11 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRAF2 |
| Gene ID | 7186 |
| Uniprot ID | TRAF2_HUMAN |
| Immunogen | Synthesized phosho peptide around human TRAF2 (Ser11) |
| Specificity | This antibody detects endogenous levels of Human Mouse TRAF2 (phospho-Ser11) |
Additional Info
| Function | E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation.this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked ubiquitination of MLST8, thereby inhibiting formation of the mTORC2 complex, while facilitating assembly of the mTORC1 complex. Required for normal antibody isotype switching from IgM to IgG. |
| Protein Name | Tnf Receptor-Associated Factor 2E3 Ubiquitin-Protein Ligase Traf2Ring-Type E3 Ubiquitin Transferase Traf2Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5668541Reactome: R-HSA-5675482Reactome: R-HSA-5676594Reactome: R-HSA-5689880Reactome: R-HSA-69416Reactome: R-HSA-75893Reactome: R-HSA-933541Reactome: R-HSA-933542Reactome: R-HSA-9693928Reactome: R-HSA-9758274 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tnf Receptor-Associated Factor 2 antibodyAnti-E3 Ubiquitin-Protein Ligase Traf2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Traf2 antibodyAnti-Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3 antibodyAnti-TRAF2 antibodyAnti-TRAP3 antibody |
Information sourced from Uniprot.org