Anti-Phospho-TNS1-Tyr1326 antibody (STJ91358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Tensin-1-Tyr1326 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNS1 |
| Gene ID | 7145 |
| Uniprot ID | TENS1_HUMAN |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326) |
| Specificity | Phospho-Tensin-1 (Y1326) Polyclonal Antibody detects endogenous levels of Tensin-1 protein only when phosphorylated at Y1326. |
Additional Info
| Post Translational Modifications | Extensively phosphorylated on serine and threonine residues in a p38 MAPK-dependent manner which reduces interaction with DLC1 and increases interaction with tyrosine-phosphorylated proteins including BCAR1/p130cas and PTK2/FAK. The majority of the phosphorylated Ser/Thr residues are immediately adjacent to a proline residue. Also phosphorylated on tyrosine residues. Rapidly cleaved by calpain II. |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. |
| Protein Name | Tensin-1 |
| Database Links | |
| Cellular Localisation | Cell SurfaceCell JunctionFocal AdhesionCytoplasmCytoskeletonLocalizes To Both Focal Adhesions And Fibrillar AdhesionsLocalized At The Cell Periphery Preferentially To Fibrillar Adhesions Rather Than To Focal AdhesionsTranslocates From The Cell Edge To The Cell Center In An Itgb1bp1-Dependent Manner |
| Alternative Antibody Names | Anti-Tensin-1 antibodyAnti-TNS1 antibodyAnti-TNS antibody |
Information sourced from Uniprot.org