Anti-Phospho-TAB2-Ser372 antibody (STJ196444)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human TAB2 (Ser372)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-Ser372 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAB2 |
| Gene ID | 23118 |
| Uniprot ID | TAB2_HUMAN |
| Immunogen | Synthesized phosho peptide around human TAB2 (Ser372) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat TAB2 (phospho-Ser372) |
Additional Info
| Post Translational Modifications | Degraded in a lysosome-dependent manner following interaction with TRIM38. SUMOylated by TRIM60.leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation. Phosphorylated. (Microbial infection) Methylated at Cys-673 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 2Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2Tak1-Binding Protein 2Tab-2Tgf-Beta-Activated Kinase 1-Binding Protein 2 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-168638Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Cellular Localisation | MembranePeripheral Membrane ProteinEndosome MembraneLysosome MembraneCytoplasmCytosolFollowing Il1 StimulationTranslocation Occurs From The Membrane To CytosolInteraction With Trim38 Promotes Translocation From Cytosol To Endosome And Lysosome |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 2 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2 antibodyAnti-Tak1-Binding Protein 2 antibodyAnti-Tab-2 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 2 antibodyAnti-TAB2 antibodyAnti-KIAA0733 antibodyAnti-MAP3K7IP2 antibody |
Information sourced from Uniprot.org