• Western blot of rat cortical lysate showing specific immunolabeling of the ~65 kDa Munc-18 protein phosphorylated at Ser513 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).
  • Immunostaining of 14 DIV rat cortical neurons showing specific labeling of Munc-18 phosphorylated at Ser513 (STJA0003694, 1:400, m red) and PSD95 (green).

Anti-Phospho-STXBP2-Ser 513 antibody (STJA0003694)

SKU:
STJA0003694-100

£442.50
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Host: Rabbit
Applications: WB/ICC
Reactivity: Rat/Bovine/Canine/Chicken/Human/Mouse/Non-Human Primates/Xenopus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Munc-18-Ser 513 is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC 1:400
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Stxbp2
Gene ID: 81804
Uniprot ID: STXB2_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser513 conjugated to KLH.
Function Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Protein Name Syntaxin-Binding Protein 2
Protein Unc-18 Homolog 2
Munc18-2
Unc18-2
Protein Unc-18 Homolog B
Unc-18b
Database Links Reactome: R-RNO-114608
Reactome: -RNO-449836
Alternative Antibody Names Anti-Syntaxin-Binding Protein 2 antibody
Anti-Protein Unc-18 Homolog 2 antibody
Anti-Munc18-2 antibody
Anti-Unc18-2 antibody
Anti-Protein Unc-18 Homolog B antibody
Anti-Unc-18b antibody
Anti-Stxbp2 antibody
Anti-Unc18b antibody

Information sourced from Uniprot.org

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