• Western blot analysis of lysates from COS7 cells treated with PMA 125ng/ml 30', using MUNC-18a (Phospho-Ser313) Antibody. The lane on the right is blocked with the phospho peptide.

Anti-Phospho-STXBP1-Ser313 antibody (279-328 aa) (STJ90471)

SKU:
STJ90471

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Syntaxin-binding protein 1-Ser313 (279-328 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STXBP1
Gene ID: 6812
Uniprot ID: STXB1_HUMAN
Immunogen Region: 279-328 aa
Specificity: Phospho-Unc18-1 (S313) Polyclonal Antibody detects endogenous levels of Unc18-1 protein only when phosphorylated at S313.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MUNC-18a around the phosphorylation site of Ser313 at the amino acid range 279-328
Function Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synapic membranes. May play a role in determining the specificity of intracellular fusion reactions.
Protein Name Syntaxin-Binding Protein 1
Munc18-1
N-Sec1
Protein Unc-18 Homolog 1
Unc18-1
Protein Unc-18 Homolog A
Unc-18a
P67
Database Links Reactome: R-HSA-181429 P61764-1
Reactome: R-HSA-181430 P61764-1
Reactome: R-HSA-210500 P61764-1
Reactome: R-HSA-212676 P61764-1
Reactome: R-HSA-264642 P61764-1
Reactome: R-HSA-422356
Reactome: R-HSA-6794361
Reactome: R-HSA-888590 P61764-1
Cellular Localisation Cytoplasm
Cytosol
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Syntaxin-Binding Protein 1 antibody
Anti-Munc18-1 antibody
Anti-N-Sec1 antibody
Anti-Protein Unc-18 Homolog 1 antibody
Anti-Unc18-1 antibody
Anti-Protein Unc-18 Homolog A antibody
Anti-Unc-18a antibody
Anti-P67 antibody
Anti-STXBP1 antibody
Anti-UNC18A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance