Anti-Phospho-STXBP1-Ser241 antibody (STJA0003693)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Munc18-1-Ser241 for use in WB and IHC in Mouse, Rat, Bovine, Canine, Chicken, Human, Non-Human Primates and Sheep samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Sheep |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000IHC 1:500 |
| Formulation | 100 ยตl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 ยตg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Stxbp1 |
| Gene ID | 20910 |
| Uniprot ID | STXB1_MOUSE |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH. |
Additional Info
| Tissue Specificity | Expressed in the inner and outer plexiform layers of the retina (at protein level). |
| Function | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions. |
| Protein Name | Syntaxin-Binding Protein 1Protein Unc-18 Homolog 1Unc18-1Protein Unc-18 Homolog AUnc-18a |
| Database Links | Reactome: R-MMU-181429Reactome: -MMU-181430Reactome: -MMU-210500Reactome: -MMU-212676Reactome: -MMU-264642Reactome: -MMU-888590 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 1 antibodyAnti-Protein Unc-18 Homolog 1 antibodyAnti-Unc18-1 antibodyAnti-Protein Unc-18 Homolog A antibodyAnti-Unc-18a antibodyAnti-Stxbp1 antibody |
Information sourced from Uniprot.org