Host: | Rabbit |
Applications: | IHC/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-Stathmin-2-Ser73 is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | STMN2 |
Gene ID: | 11075 |
Uniprot ID: | STMN2_HUMAN |
Specificity: | Phospho-SCG10 (S73) Polyclonal Antibody detects endogenous levels of SCG10 protein only when phosphorylated at S73. |
Immunogen: | Synthesized phospho-peptide around the phosphorylation site of human SCG10 (phospho Ser73) |
Post Translational Modifications | Sumoylated. Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15. |
Function | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. |
Protein Name | Stathmin-2 Superior Cervical Ganglion-10 Protein Protein Scg10 |
Database Links | Reactome: R-HSA-9696273 |
Cellular Localisation | Cytoplasm Perinuclear Region Cell Projection Growth Cone Membrane Peripheral Membrane Protein Cytoplasmic Side Axon Golgi Apparatus Endosome Lamellipodium Associated With Punctate Structures In The Perinuclear Cytoplasm Axons And Growth Cones Of Developing Neurons Scg10 Exists In Both Soluble And Membrane-Bound Forms Colocalized With Cib1 In Neurites Of Developing Hippocampal Primary Neurons Colocalized With Cib1 In The Cell Body Neuritis And Growth Cones Of Neurons Colocalized With Cib1 To The Leading Edge Of Lamellipodia |
Alternative Antibody Names | Anti-Stathmin-2 antibody Anti-Superior Cervical Ganglion-10 Protein antibody Anti-Protein Scg10 antibody Anti-STMN2 antibody Anti-SCG10 antibody Anti-SCGN10 antibody |
Information sourced from Uniprot.org