Anti-Phospho-STAM2-Tyr192 antibody (161-210 aa) (STJ90559)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human STAM2 around the phosphorylation site of Tyr192 at the amino acid range 161-210
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Signal transducing adapter molecule 2-Tyr192 (161-210 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAM2 |
| Gene ID | 10254 |
| Uniprot ID | STAM2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human STAM2 around the phosphorylation site of Tyr192 at the amino acid range 161-210 |
| Immunogen Region | 161-210 aa |
| Specificity | Phospho-STAM2 (Y192) Polyclonal Antibody detects endogenous levels of STAM2 protein only when phosphorylated at Y192. |
Additional Info
| Post Translational Modifications | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
| Protein Name | Signal Transducing Adapter Molecule 2Stam-2Hrs-Binding Protein |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689880Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Signal Transducing Adapter Molecule 2 antibodyAnti-Stam-2 antibodyAnti-Hrs-Binding Protein antibodyAnti-STAM2 antibodyAnti-HBP antibody |
Information sourced from Uniprot.org