| Post Translational Modifications | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated at Thr-484 in response to insulin in adipocytes. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development. |
| Protein Name | Serine/Threonine-Protein Kinase Sik2Qin-Induced KinaseSalt-Inducible Kinase 2Sik-2Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 |
| Database Links | |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sik2 antibodyAnti-Qin-Induced Kinase antibodyAnti-Salt-Inducible Kinase 2 antibodyAnti-Sik-2 antibodyAnti-Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 antibodyAnti-SIK2 antibodyAnti-KIAA0781 antibodyAnti-QIK antibodyAnti-SNF1LK2 antibody |
Information sourced from Uniprot.org
