Anti-Phospho-RCC1-Ser11 antibody (STJ194740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human RCC1 (Ser11)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Regulator of chromosome condensation-Ser11 for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCC1 |
| Gene ID | 1104 |
| Uniprot ID | RCC1_HUMAN |
| Immunogen | Synthesized phosho peptide around human RCC1 (Ser11) |
| Specificity | This antibody detects endogenous levels of Human RCC1 (phospho-Ser11) |
Additional Info
| Function | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. |
| Protein Name | Regulator Of Chromosome CondensationCell Cycle Regulatory ProteinChromosome Condensation Protein 1 |
| Database Links | Reactome: R-HSA-165054Reactome: R-HSA-180746Reactome: R-HSA-9615933 |
| Cellular Localisation | NucleusChromosomeCytoplasmPredominantly Nuclear In Interphase CellsBinds To Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Regulator Of Chromosome Condensation antibodyAnti-Cell Cycle Regulatory Protein antibodyAnti-Chromosome Condensation Protein 1 antibodyAnti-RCC1 antibodyAnti-CHC1 antibody |
Information sourced from Uniprot.org