Anti-Phospho-PXN-Thr-538 antibody (STJA0005518)

SKU:
STJA0005518-100

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Host: Rabbit
Applications: WB
Reactivity: Chicken/Human/Mouse/Rat/Xenopus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Paxillin-Thr-538 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PXN
Gene ID: 5829
Uniprot ID: PAXI_HUMAN
Specificity: This antibody detects a 68kDa* protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells treated with calyculin A. This reactivity is not observed after lambda phosphatase treatment.
Immunogen: Phospho-Paxillin (Thr-538) synthetic peptide (coupled to KLH) corresponding to amino acid residues around threonine 538 from human paxillin a. This sequence is highly conserved in rat and mouse paxillin and is also found in the other paxillin isoform
Function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.
Protein Name Paxillin
Database Links Reactome: R-HSA-180292
Reactome: R-HSA-4420097
Reactome: R-HSA-445355
Reactome: R-HSA-446343
Reactome: R-HSA-446388
Reactome: R-HSA-8849471
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Junction
Focal Adhesion
Cell Cortex
Colocalizes With Integrins At The Cell Periphery
Colocalize With Pxn To Membrane Ruffles And The Leading Edge Of Migrating Cells
Alternative Antibody Names Anti-Paxillin antibody
Anti-PXN antibody

Information sourced from Uniprot.org

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