Anti-Phospho-PXN-Ser-83 antibody (STJA0005515)

SKU:
STJA0005515-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Paxillin-Ser-83 is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC 1:50
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Pxn
Gene ID: 19303
Uniprot ID: PAXI_MOUSE
Specificity: The antibody detects a 68kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of NGF treated rat PC12 cells, as well as calyculin A treated human A431 cells and mouse macrophages.
Immunogen: Phospho-Paxillin (Ser-83) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 83 of mouse paxillin. This sequence is highly conserved in rat and human paxillin and is also found in all isoforms (a, b, g) of paxillin.
Function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion.
Protein Name Paxillin
Database Links Reactome: R-MMU-180292
Reactome: -MMU-4420097
Reactome: -MMU-445355
Reactome: -MMU-446343
Reactome: -MMU-446388
Reactome: -MMU-8849471
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Junction
Focal Adhesion
Cell Cortex
Colocalizes With Integrins At The Cell Periphery
Colocalizes With Pxn To Membrane Ruffles And The Leading Edge Of Migrating Cells
Alternative Antibody Names Anti-Paxillin antibody
Anti-Pxn antibody

Information sourced from Uniprot.org

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