Anti-Phospho-PSEN2-Ser330 antibody (296-345 aa) (STJ91184)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Presenilin 2 around the phosphorylation site of Ser330 at the amino acid range 296-345
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Presenilin-2-Ser330 (296-345 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSEN2 |
| Gene ID | 5664 |
| Uniprot ID | PSN2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Presenilin 2 around the phosphorylation site of Ser330 at the amino acid range 296-345 |
| Immunogen Region | 296-345 aa |
| Specificity | Phospho-Presenilin 2 (S330) Polyclonal Antibody detects endogenous levels of Presenilin 2 protein only when phosphorylated at S330. |
Additional Info
| Post Translational Modifications | Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues. |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
| Protein Name | Presenilin-2Ps-2Ad3lpAd5E5-1Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-9839383 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Presenilin-2 antibodyAnti-Ps-2 antibodyAnti-Ad3lp antibodyAnti-Ad5 antibodyAnti-E5-1 antibodyAnti-Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit antibodyAnti-PSEN2 antibodyAnti-AD4 antibodyAnti-PS2 antibodyAnti-PSNL2 antibodyAnti-STM2 antibody |
Information sourced from Uniprot.org