Anti-Phospho-PLEKHG5-Ser881 antibody (STJ198348)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PLEKHG5 (Phospho-ser881)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Pleckstrin homology domain-containing family G member 5-Ser881 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLEKHG5 |
| Gene ID | 57449 |
| Uniprot ID | PKHG5_HUMAN |
| Immunogen | Synthesized peptide derived from the human PLEKHG5 (Phospho-ser881) |
| Specificity | This antibody detects endogenous levels of PLEKHG5 (Phospho-ser881) at Human, Mouse, Rat |
Additional Info
| Function | Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts. |
| Protein Name | Pleckstrin Homology Domain-Containing Family G Member 5Ph Domain-Containing Family G Member 5Guanine Nucleotide Exchange Factor 720Gef720 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneCell JunctionCell ProjectionLamellipodiumPredominantly CytoplasmicHowever When Endothelial Cells Are Stimulated With Lysophosphatidic AcidPlekhg5 Is Found In Perinuclear Regions And At The Cell MembraneLocalizes At Cell-Cell Junctions In Quiescent Endothelial CellsAnd Relocalizes To Cytoplasmic Vesicle And The Leading Edge Of Lamellipodia In Migrating Endothelial Cells |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family G Member 5 antibodyAnti-Ph Domain-Containing Family G Member 5 antibodyAnti-Guanine Nucleotide Exchange Factor 720 antibodyAnti-Gef720 antibodyAnti-PLEKHG5 antibodyAnti-KIAA0720 antibody |
Information sourced from Uniprot.org