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Anti-Phospho-PLCG2-Y759 antibody (STJ117883)

Western blot analysis of extracts of Raji cells, using Phospho-PLCG2-Y759 antibody (STJ117883) at 1:2000 dilution or PLCG2 antibody (A2182). Raji cells were treated by Pervanadate (1 mM) at 37 °C for 30 minutes. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 1s.
Western blot analysis of Raji, using Phospho-PLC gamma 2 (PLCG2) -Y759 Rabbit polyclonal antibody (STJ117883) at 1:2000 dilution. Raji cells were treated by Pervanadate (1 mM) at 37 °C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Western blot analysis of extracts of Raji cells, using Phospho-PLCG2-Y759 polyclonal antibody (STJ117883) at 1:2000 dilution or PLCG2 antibody (A2182). Raji cells were treated by Pervanadate (1 mM) at 37 °C for 30 minutes. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-Phospho-PLCG2-Y759 antibody (STJ117883)

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STJ117883

£212.50 - £501.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-PLCG2-Y759 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PLCG2
Gene ID:	5336
Uniprot ID:	PLCG2_HUMAN
Immunogen:	A synthetic phosphorylated peptide around Y759 of human PLC gamma 2 (PLCG2) (NP_002652.2).
Immunogen Sequence:	RMYVD

Post Translational Modifications	Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK.upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.
Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Protein Name	1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 Phosphoinositide Phospholipase C-Gamma-2 Phospholipase C-Iv Plc-Iv Phospholipase C-Gamma-2 Plc-Gamma-2
Database Links	Reactome: R-HSA-114604 Reactome: R-HSA-166016 Reactome: R-HSA-1855204 Reactome: R-HSA-202433 Reactome: R-HSA-2029485 Reactome: R-HSA-2424491 Reactome: R-HSA-2871796 Reactome: R-HSA-2871809 Reactome: R-HSA-5607764 Reactome: R-HSA-5621480 Reactome: R-HSA-9027277 Reactome: R-HSA-9664323 Reactome: R-HSA-9679191 Reactome: R-HSA-9680350 Reactome: R-HSA-983695
Cellular Localisation	Membrane Raft
Alternative Antibody Names	Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibody Anti-Phosphoinositide Phospholipase C-Gamma-2 antibody Anti-Phospholipase C-Iv antibody Anti-Plc-Iv antibody Anti-Phospholipase C-Gamma-2 antibody Anti-Plc-Gamma-2 antibody Anti-PLCG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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