Anti-Phospho-PLC-Gamma-Y783 antibody [SAA0303] (STJA0019172)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Phospho-1-Phosphatidylinositol 4-5-Bisphosphate Phosphodiesterase Gamma-1-Y783 antibody for use in IHC, IP and WB in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0303 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | PLCG1 |
| Gene ID | 5335 |
| Uniprot ID | PLCG1_HUMAN |
Additional Info
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1Plc-148Phosphoinositide Phospholipase C-Gamma-1Phospholipase C-IiPlc-IiPhospholipase C-Gamma-1Plc-Gamma-1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-1236382Reactome: R-HSA-1251932Reactome: R-HSA-1489509Reactome: R-HSA-167021Reactome: R-HSA-1855204Reactome: R-HSA-186763Reactome: R-HSA-201556Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-210990Reactome: R-HSA-212718Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-418890Reactome: R-HSA-5218921Reactome: R-HSA-5637810Reactome: R-HSA-5654219Reactome: R-HSA-5654221Reactome: R-HSA-5654227Reactome: R-HSA-5654228Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-8853659Reactome: R-HSA-9026527Reactome: R-HSA-9027277Reactome: R-HSA-9034793Reactome: R-HSA-9664323Reactome: R-HSA-9664565Reactome: R-HSA-9665348Reactome: R-HSA-9665686Reactome: R-HSA-9725370 |
| Cellular Localisation | Cell ProjectionLamellipodiumRuffleRapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 antibodyAnti-Plc-148 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-1 antibodyAnti-Phospholipase C-Ii antibodyAnti-Plc-Ii antibodyAnti-Phospholipase C-Gamma-1 antibodyAnti-Plc-Gamma-1 antibodyAnti-PLCG1 antibodyAnti-PLC1 antibody |
Information sourced from Uniprot.org