Anti-Phospho-PAK6-Ser-165 antibody (STJA0005511)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenPAK6 (Ser-165) synthetic peptide (coupled to carrier protein) corresponding to amino acids around serine 165 in human PAK6. The sequence used has two amino acid differences compared to rat and mouse PAK6.
General Information
| Short Description | Rabbit polyclonal antibody anti-Phospho-PAK6-Ser-165 is suitable for use in Western Blot research applications. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAK6 |
| Gene ID | 106821730/56924 |
| Uniprot ID | PAK6_HUMAN |
| Immunogen | PAK6 (Ser-165) synthetic peptide (coupled to carrier protein) corresponding to amino acids around serine 165 in human PAK6. The sequence used has two amino acid differences compared to rat and mouse PAK6. |
| Specificity | This antibody was cross-adsorbed to unphosphorylated PAK6 (Ser-165) peptide then affinity purified using phospho-PAK6 (Ser-165) peptide. The antibody detects a 75 kDa* band on SDS-PAGE immunoblots of human PAK6 recombinant protein phosphorylated with |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. |
| Function | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. |
| Protein Name | Serine/Threonine-Protein Kinase Pak 6Pak-5P21-Activated Kinase 6Pak-6 |
| Database Links | Reactome: R-HSA-428540Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013405Reactome: R-HSA-9013407Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmNucleusCotranslocates Into Nucleus With Ar In Response To Androgen Induction |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Pak 6 antibodyAnti-Pak-5 antibodyAnti-P21-Activated Kinase 6 antibodyAnti-Pak-6 antibodyAnti-PAK6 antibodyAnti-PAK5 antibody |
Information sourced from Uniprot.org