Anti-Phospho-OPRD1-Ser363 antibody (323-372 aa) (STJ90786)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Opioid Receptor-delta around the phosphorylation site of Ser363 at the amino acid range 323-372
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Delta-type opioid receptor-Ser363 (323-372 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OPRD1 |
| Gene ID | 4985 |
| Uniprot ID | OPRD_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Opioid Receptor-delta around the phosphorylation site of Ser363 at the amino acid range 323-372 |
| Immunogen Region | 323-372 aa |
| Specificity | Phospho-DOR-1 (S363) Polyclonal Antibody detects endogenous levels of DOR-1 protein only when phosphorylated at S363. |
Additional Info
| Post Translational Modifications | N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation.the ubiquitination is diminished by RTP4. |
| Function | G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
| Protein Name | Delta-Type Opioid ReceptorD-Or-1Dor-1 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Delta-Type Opioid Receptor antibodyAnti-D-Or-1 antibodyAnti-Dor-1 antibodyAnti-OPRD1 antibodyAnti-OPRD antibody |
Information sourced from Uniprot.org