• Western blot analysis of lysates from 293 cells treated with TSA 400nM 24h, using Opioid Receptor-delta (Phospho-Ser363) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Immunohistochemistry analysis of paraffin-embedded human brain, using Opioid Receptor-delta (Phospho-Ser363) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of 293 cells using Phospho-DOR-1 (S363) Polyclonal Antibody

Anti-Phospho-OPRD1-Ser363 antibody (323-372 aa) (STJ90786)

SKU:
STJ90786

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Delta-type opioid receptor-Ser363 (323-372 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OPRD1
Gene ID: 4985
Uniprot ID: OPRD_HUMAN
Immunogen Region: 323-372 aa
Specificity: Phospho-DOR-1 (S363) Polyclonal Antibody detects endogenous levels of DOR-1 protein only when phosphorylated at S363.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Opioid Receptor-delta around the phosphorylation site of Ser363 at the amino acid range 323-372
Post Translational Modifications N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation.the ubiquitination is diminished by RTP4.
Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Protein Name Delta-Type Opioid Receptor
D-Or-1
Dor-1
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Reactome: R-HSA-6785807
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Delta-Type Opioid Receptor antibody
Anti-D-Or-1 antibody
Anti-Dor-1 antibody
Anti-OPRD1 antibody
Anti-OPRD antibody

Information sourced from Uniprot.org

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