Anti-Phospho-NUMB-Ser276 antibody (STJ196369)

SKU:
STJ196369

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Protein numb homolog-Ser276 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NUMB
Gene ID: 8650
Uniprot ID: NUMB_HUMAN
Specificity: This antibody detects endogenous levels of Human Numb (phospho-Ser276)
Immunogen: Synthesized phosho peptide around human Numb (Ser276)
Function Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Protein Name Protein Numb Homolog
H-Numb
Protein S171
Database Links Reactome: R-HSA-2122948
Reactome: R-HSA-437239
Reactome: R-HSA-5610780
Reactome: R-HSA-5632684
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Endosome Membrane
Localizes To Perinuclear Endosomes In An Aak1-Dependent Manner
Alternative Antibody Names Anti-Protein Numb Homolog antibody
Anti-H-Numb antibody
Anti-Protein S171 antibody
Anti-NUMB antibody
Anti-C14orf41 antibody

Information sourced from Uniprot.org

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