Anti-Phospho-NKX2-1-Ser327 antibody (STJ194753)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human TTF-1 (Ser327)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Homeobox protein Nkx-2.1-Ser327 for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKX2-1 |
| Gene ID | 7080 |
| Uniprot ID | NKX21_HUMAN |
| Immunogen | Synthesized phosho peptide around human TTF-1 (Ser327) |
| Specificity | This antibody detects endogenous levels of Human TTF-1 (phospho-Ser327) |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1Homeobox Protein Nk-2 Homolog AThyroid Nuclear Factor 1Thyroid Transcription Factor 1Ttf-1Thyroid-Specific Enhancer-Binding ProteinT/Ebp |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibodyAnti-Homeobox Protein Nk-2 Homolog A antibodyAnti-Thyroid Nuclear Factor 1 antibodyAnti-Thyroid Transcription Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Thyroid-Specific Enhancer-Binding Protein antibodyAnti-T/Ebp antibodyAnti-NKX2-1 antibodyAnti-NKX2A antibodyAnti-TITF1 antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org