Anti-Phospho-NCOA1-Thr1179 antibody (STJA0009849)

SKU:
STJA0009849

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Nuclear receptor coactivator 1-Thr1179 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NCOA1
Gene ID: 8648
Uniprot ID: NCOA1_HUMAN
Specificity: This antibody detects endogenous levels of Human, Mouse SRC-1 (Phospho Thr1179)
Immunogen: Synthesized peptide derived from human SRC-1 (Phospho Thr1179)
Tissue Specificity Widely expressed.
Post Translational Modifications Sumoylated.sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein. Ubiquitinated.leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4.the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Protein Name Nuclear Receptor Coactivator 1
Ncoa-1
Class E Basic Helix-Loop-Helix Protein 74
Bhlhe74
Protein Hin-2
Rip160
Renal Carcinoma Antigen Ny-Ren-52
Steroid Receptor Coactivator 1
Src-1
Database Links Reactome: R-HSA-1368082
Reactome: R-HSA-1368108
Reactome: R-HSA-159418
Reactome: R-HSA-192105
Reactome: R-HSA-193368
Reactome: R-HSA-193807
Reactome: R-HSA-1989781
Reactome: R-HSA-211976
Reactome: R-HSA-2151201
Reactome: R-HSA-2426168
Reactome: R-HSA-3214847
Reactome: R-HSA-381340
Reactome: R-HSA-3899300
Reactome: R-HSA-400206
Reactome: R-HSA-400253
Reactome: R-HSA-9018519
Reactome: R-HSA-9029569
Reactome: R-HSA-9623433
Reactome: R-HSA-9707564
Reactome: R-HSA-9707616
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Nuclear Receptor Coactivator 1 antibody
Anti-Ncoa-1 antibody
Anti-Class E Basic Helix-Loop-Helix Protein 74 antibody
Anti-Bhlhe74 antibody
Anti-Protein Hin-2 antibody
Anti-Rip160 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-52 antibody
Anti-Steroid Receptor Coactivator 1 antibody
Anti-Src-1 antibody
Anti-NCOA1 antibody
Anti-BHLHE74 antibody
Anti-SRC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance