Anti-Phospho-MYH9-Ser1943 antibody (STJ196360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human Myosin IIa (Ser1943)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Myosin-9-Ser1943 for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYH9 |
| Gene ID | 4627 |
| Uniprot ID | MYH9_HUMAN |
| Immunogen | Synthesized phosho peptide around human Myosin IIa (Ser1943) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat Myosin IIa (phospho-Ser1943) |
Additional Info
| Post Translational Modifications | ISGylated. Ubiquitination. |
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction.this function is mechanically antagonized by MYH10. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. |
| Protein Name | Myosin-9Cellular Myosin Heavy Chain - Type AMyosin Heavy Chain 9Myosin Heavy Chain - Non-Muscle IiaNon-Muscle Myosin Heavy Chain ANmmhc-ANon-Muscle Myosin Heavy Chain IiaNmmhc Ii-ANmmhc-Iia |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-2029482Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9662834Reactome: R-HSA-9664422Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesicleSecretory VesicleCortical GranuleCell MembraneColocalizes With Actin Filaments At Lamellipodia Margins And At The Leading Edge Of Migrating CellsIn Retinal Pigment Epithelial CellsPredominantly Localized To Stress Fiber-Like Structures With Some Localization To Cytoplasmic Puncta(Microbial Infection) Localizes At The Surface Of The Cell Membrane Following Infection By Herpes Simplex Virus 1/Hhv-1 |
| Alternative Antibody Names | Anti-Myosin-9 antibodyAnti-Cellular Myosin Heavy Chain - Type A antibodyAnti-Myosin Heavy Chain 9 antibodyAnti-Myosin Heavy Chain - Non-Muscle Iia antibodyAnti-Non-Muscle Myosin Heavy Chain A antibodyAnti-Nmmhc-A antibodyAnti-Non-Muscle Myosin Heavy Chain Iia antibodyAnti-Nmmhc Ii-A antibodyAnti-Nmmhc-Iia antibodyAnti-MYH9 antibody |
Information sourced from Uniprot.org