| Short Description : | Rabbit polyclonal anti-Phospho-Protein max-Ser2 (1-50 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAX |
| Gene ID: | 4149 |
| Uniprot ID: | MAX_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MAX around the phosphorylation site of Ser2 at the amino acid range 1-50 |
| Immunogen Region: | 1-50 aa |
| Specificity: | Phospho-Max (S2) Polyclonal Antibody detects endogenous levels of Max protein only when phosphorylated at S2. |
| Post Translational Modifications | Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes. |
| Function | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CACGATG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. |
| Protein Name | Protein MaxClass D Basic Helix-Loop-Helix Protein 4Bhlhd4Myc-Associated Factor X |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-69202Reactome: R-HSA-69656Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Protein Max antibodyAnti-Class D Basic Helix-Loop-Helix Protein 4 antibodyAnti-Bhlhd4 antibodyAnti-Myc-Associated Factor X antibodyAnti-MAX antibodyAnti-BHLHD4 antibody |
Information sourced from Uniprot.org
