Anti-Phospho-MAP3K12 antibody (270-320) {FITC} (STJ502554)

SKU:
STJ502554-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-MAP3K12 (270-320) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.68 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MAP3K12
Gene ID: 7786
Uniprot ID: M3K12_HUMAN
Immunogen Region: 270-320
Immunogen: Synthetic peptide taken within amino acid region 270-320 on MAP3K12 protein. Phosphorylated S298 & S302 residues.
Tissue Specificity Highly expressed in brain and kidney.
Post Translational Modifications Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.
Function Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 12
Dual Leucine Zipper Bearing Kinase
Dlk
Leucine-Zipper Protein Kinase
Zpk
Mapk-Upstream Kinase
Muk
Mixed Lineage Kinase
Cellular Localisation Cytoplasm
Cell Membrane
Behaves Essentially As An Integral Membrane Protein
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 antibody
Anti-Dual Leucine Zipper Bearing Kinase antibody
Anti-Dlk antibody
Anti-Leucine-Zipper Protein Kinase antibody
Anti-Zpk antibody
Anti-Mapk-Upstream Kinase antibody
Anti-Muk antibody
Anti-Mixed Lineage Kinase antibody
Anti-MAP3K12 antibody
Anti-ZPK antibody

Information sourced from Uniprot.org

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