Anti-Phospho-MAP3K12 antibody (270-320) {FITC} (STJ502554)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 270-320 on MAP3K12 protein. Phosphorylated S298 & S302 residues.
General Information
| Short Description | Rabbit polyclonal antibody anti-Phospho-MAP3K12 (270-320) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.68 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP3K12 |
| Gene ID | 7786 |
| Uniprot ID | M3K12_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 270-320 on MAP3K12 protein. Phosphorylated S298 & S302 residues. |
| Immunogen Region | 270-320 |
Additional Info
| Tissue Specificity | Highly expressed in brain and kidney. |
| Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
| Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 12Dual Leucine Zipper Bearing KinaseDlkLeucine-Zipper Protein KinaseZpkMapk-Upstream KinaseMukMixed Lineage Kinase |
| Cellular Localisation | CytoplasmCell MembraneBehaves Essentially As An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 antibodyAnti-Dual Leucine Zipper Bearing Kinase antibodyAnti-Dlk antibodyAnti-Leucine-Zipper Protein Kinase antibodyAnti-Zpk antibodyAnti-Mapk-Upstream Kinase antibodyAnti-Muk antibodyAnti-Mixed Lineage Kinase antibodyAnti-MAP3K12 antibodyAnti-ZPK antibody |
Information sourced from Uniprot.org