| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Keratin, type I cytoskeletal 20-Ser13 is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KRT20 |
| Gene ID: | 54474 |
| Uniprot ID: | K1C20_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human Keratin 20 (phospho-Ser13) |
| Immunogen: | Synthesized phosho peptide around human Keratin 20 (Ser13) |
| Post Translational Modifications | Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury. Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. |
| Function | Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. |
| Protein Name | Keratin - Type I Cytoskeletal 20 Cytokeratin-20 Ck-20 Keratin-20 K20 Protein It |
| Database Links | Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 20 antibody Anti-Cytokeratin-20 antibody Anti-Ck-20 antibody Anti-Keratin-20 antibody Anti-K20 antibody Anti-Protein It antibody Anti-KRT20 antibody |
Information sourced from Uniprot.org