Anti-Phospho-KIZ-Thr379 antibody (STJA0009998)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Kizuna (Phospho-Thr379)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Centrosomal protein kizuna-Thr379 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIZ |
| Gene ID | 55857 |
| Uniprot ID | KIZ_HUMAN |
| Immunogen | Synthesized peptide derived from human Kizuna (Phospho-Thr379) |
| Specificity | This antibody detects endogenous levels of Kizuna (Phospho-Thr379) at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization. |
| Function | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. |
| Protein Name | Centrosomal Protein KizunaPolo-Like Kinase 1 Substrate 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCilium Basal BodyLocalizes To Centrosomes Throughout The Cell CycleAfter Centrosome DuplicationIt Usually Remains Associated Only With The Mother CentrosomeContaining The Older Mature Centriole And Particles Surrounding ItDuring ProphaseAdditional Particles Accumulate Around Both Separating CentrosomesDoes Not Accumulate At The Microtubule Minus EndsBut Instead Localizes To The Centrosomes And Centrosome-Surrounding Area In A Microtubule-Independent And Dependent MannerRespectively |
| Alternative Antibody Names | Anti-Centrosomal Protein Kizuna antibodyAnti-Polo-Like Kinase 1 Substrate 1 antibodyAnti-KIZ antibodyAnti-C20orf19 antibodyAnti-NCRNA00153 antibodyAnti-PLK1S1 antibodyAnti-HT013 antibody |
Information sourced from Uniprot.org