Anti-Phospho-KIRREL-p737/738 antibody {Biotin} (STJ502568)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenPhosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.
General Information
| Short Description | Rabbit polyclonal antibody anti-Phospho-KIRREL-p737/738 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | CM/ELISA/ICC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Chicken/Human/Mouse/Rat/Zebra Fish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.45-0.65 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:250DB: 1:10, 000ELISA: 1:10, 000IP: 1:250IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Kirrel1 |
| Gene ID | 170643 |
| Uniprot ID | KIRR1_MOUSE |
| Immunogen | Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1. |
| Specificity | Intracelular domain. |
Additional Info
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
| Post Translational Modifications | Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated. |
| Function | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
| Protein Name | Kin Of Irre-Like Protein 1Kin Of Irregular Chiasm-Like Protein 1Nephrin-Like Protein 1 |
| Database Links | Reactome: R-MMU-373753 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPredominantly Located At Podocyte Slit Diaphragm |
| Alternative Antibody Names | Anti-Kin Of Irre-Like Protein 1 antibodyAnti-Kin Of Irregular Chiasm-Like Protein 1 antibodyAnti-Nephrin-Like Protein 1 antibodyAnti-Kirrel1 antibodyAnti-Kirrel antibodyAnti-Neph1 antibody |
Information sourced from Uniprot.org