| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Kinesin-like protein KIF2C-Ser95 (61-110 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIF2C |
| Gene ID: |
11004 |
| Uniprot ID: |
KIF2C_HUMAN |
| Immunogen Region: |
61-110 aa |
| Specificity: |
Phospho-KIF2C (S95) Polyclonal Antibody detects endogenous levels of KIF2C protein only when phosphorylated at S95. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KIF2C around the phosphorylation site of Ser95 at the amino acid range 61-110 |
| Post Translational Modifications | Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. Ubiquitinated. |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. |
| Protein Name | Kinesin-Like Protein Kif2cKinesin-Like Protein 6Mitotic Centromere-Associated KinesinMcak |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-6811434Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusChromosomeCentromereKinetochoreAssociates With The Microtubule Network At The Growing Distal Tip (The Plus-End) Of MicrotubulesProbably Through Interaction With Mtus2/Tip150 And Mapre1Association With Microtubule Plus Ends Is Also Mediated By Interaction With Kif18bCentromeric Localization Requires The Presence Of Bub1 And Sgo2 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif2c antibodyAnti-Kinesin-Like Protein 6 antibodyAnti-Mitotic Centromere-Associated Kinesin antibodyAnti-Mcak antibodyAnti-KIF2C antibodyAnti-KNSL6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
