• Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Phospho-IRS1-Ser636/639 antibody (STJ196337)

SKU:
STJ196337

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Insulin receptor substrate 1-Ser636/639 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IRS1
Gene ID: 3667
Uniprot ID: IRS1_HUMAN
Specificity: This antibody detects endogenous levels of Human Mouse Rat IRS-1 (phospho-Ser636 or 639)
Immunogen: Synthesized phosho peptide around human IRS-1 (Ser636 and 639)
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Protein Name Insulin Receptor Substrate 1
Irs-1
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-112399
Reactome: R-HSA-112412
Reactome: R-HSA-1257604
Reactome: R-HSA-1266695
Reactome: R-HSA-198203
Reactome: R-HSA-201556
Reactome: R-HSA-2219530
Reactome: R-HSA-2428928
Reactome: R-HSA-2586552
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-74713
Reactome: R-HSA-74749
Reactome: R-HSA-9603381
Reactome: R-HSA-9725370
Reactome: R-HSA-982772
Alternative Antibody Names Anti-Insulin Receptor Substrate 1 antibody
Anti-Irs-1 antibody
Anti-IRS1 antibody

Information sourced from Uniprot.org

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