| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Interleukin-1 receptor type 1-Tyr496 (471-520 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL1R1 |
| Gene ID: |
3554 |
| Uniprot ID: |
IL1R1_HUMAN |
| Immunogen Region: |
471-520 aa |
| Specificity: |
Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496 at the amino acid range 471-520 |
| Post Translational Modifications | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Protein Name | Interleukin-1 Receptor Type 1Il-1r-1Il-1rt-1Il-1rt1Cd121 Antigen-Like Family Member AInterleukin-1 Receptor AlphaIl-1r-AlphaInterleukin-1 Receptor Type IP80Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane FormMil-1r1Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble FormSil-1r1Sil-1ri |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702Reactome: R-HSA-9679191 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell MembraneSecreted |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Type 1 antibodyAnti-Il-1r-1 antibodyAnti-Il-1rt-1 antibodyAnti-Il-1rt1 antibodyAnti-Cd121 Antigen-Like Family Member A antibodyAnti-Interleukin-1 Receptor Alpha antibodyAnti-Il-1r-Alpha antibodyAnti-Interleukin-1 Receptor Type I antibodyAnti-P80 antibodyAnti-Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form antibodyAnti-Mil-1r1 antibodyAnti-Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form antibodyAnti-Sil-1r1 antibodyAnti-Sil-1ri antibodyAnti-IL1R1 antibodyAnti-IL1R antibodyAnti-IL1RA antibodyAnti-IL1RT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
