Anti-Phospho-HNF1A-Ser247 antibody (STJ196322)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human HNF1 Alpha (Ser247)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Hepatocyte nuclear factor 1-alpha-Ser247 for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HNF1A |
| Gene ID | 6927 |
| Uniprot ID | HNF1A_HUMAN |
| Immunogen | Synthesized phosho peptide around human HNF1 Alpha (Ser247) |
| Specificity | This antibody detects endogenous levels of Human HNF1 Alpha (phospho-Ser247) |
Additional Info
| Post Translational Modifications | Ubiquitinated in s SPOP-dependent manner.leading to prteasomal degradation. |
| Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). |
| Protein Name | Hepatocyte Nuclear Factor 1-AlphaHnf-1-AlphaHnf-1aLiver-Specific Transcription Factor Lf-B1Lfb1Transcription Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 1-Alpha antibodyAnti-Hnf-1-Alpha antibodyAnti-Hnf-1a antibodyAnti-Liver-Specific Transcription Factor Lf-B1 antibodyAnti-Lfb1 antibodyAnti-Transcription Factor 1 antibodyAnti-Tcf-1 antibodyAnti-HNF1A antibodyAnti-TCF1 antibody |
Information sourced from Uniprot.org