Anti-Phospho-HCLS1-Tyr378 antibody (STJ90643)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phospho-peptide around the phosphorylation site of human Lck BP-1 (phospho Tyr378)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Hematopoietic lineage cell-specific protein-Tyr378 for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCLS1 |
| Gene ID | 3059 |
| Uniprot ID | HCLS1_HUMAN |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Lck BP-1 (phospho Tyr378) |
| Specificity | Phospho-Lck BP-1 (Y378) Polyclonal Antibody detects endogenous levels of Lck BP-1 protein only when phosphorylated at Y378. |
Additional Info
| Post Translational Modifications | Phosphorylated by FES. Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. |
| Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| Protein Name | Hematopoietic Lineage Cell-Specific ProteinHematopoietic Cell-Specific Lyn Substrate 1Lckbp1P75 |
| Database Links | |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Hematopoietic Lineage Cell-Specific Protein antibodyAnti-Hematopoietic Cell-Specific Lyn Substrate 1 antibodyAnti-Lckbp1 antibodyAnti-P75 antibodyAnti-HCLS1 antibodyAnti-HS1 antibody |
Information sourced from Uniprot.org