• Western blot of rat cerebellar lysate showing specific immunolabeling of the ~140 kDa NR2C subunit of the NMDA receptor phosphorylated at Ser1244 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).

Anti-Phospho-GRIN2C-Ser1244 antibody (STJA0003726)

SKU:
STJA0003726-100

$613.58
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat/Bovine/Canine/Human/Non-Human Primates
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-NMDAR2C-Ser1244 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Grin2c
Gene ID: 24411
Uniprot ID: NMDE3_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1244 conjugated to KLH.
Tissue Specificity Detected in cerebellum.
Function Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Protein Name Glutamate Receptor Ionotropic - Nmda 2c
Glun2c
Glutamate Nmda Receptor Subunit Epsilon-3
N-Methyl D-Aspartate Receptor Subtype 2c
Nmdar2c
Nr2c
Database Links Reactome: R-RNO-438066
Reactome: -RNO-8849932
Reactome: -RNO-9609736
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Antibody Names Anti-Glutamate Receptor Ionotropic - Nmda 2c antibody
Anti-Glun2c antibody
Anti-Glutamate Nmda Receptor Subunit Epsilon-3 antibody
Anti-N-Methyl D-Aspartate Receptor Subtype 2c antibody
Anti-Nmdar2c antibody
Anti-Nr2c antibody
Anti-Grin2c antibody

Information sourced from Uniprot.org

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