Anti-Phospho-GRIN1-Ser897 antibody (864-913 aa) (STJ91010)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human NMDAR1 around the phosphorylation site of Ser897 at the amino acid range 864-913
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Glutamate receptor ionotropic, NMDA 1-Ser897 (864-913 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRIN1 |
| Gene ID | 2902 |
| Uniprot ID | NMDZ1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human NMDAR1 around the phosphorylation site of Ser897 at the amino acid range 864-913 |
| Immunogen Region | 864-913 aa |
| Specificity | Phospho-NMDA Zeta 1 (S897) Polyclonal Antibody detects endogenous levels of NMDA Zeta 1 protein only when phosphorylated at S897. |
Additional Info
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1Glun1Glutamate Nmda Receptor Subunit Zeta-1N-Methyl-D-Aspartate Receptor Subunit Nr1Nmd-R1Hnr1 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneSynaptic Cell MembraneSynaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b SubunitAssociation With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 1 antibodyAnti-Glun1 antibodyAnti-Glutamate Nmda Receptor Subunit Zeta-1 antibodyAnti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibodyAnti-Nmd-R1 antibodyAnti-Hnr1 antibodyAnti-GRIN1 antibodyAnti-NMDAR1 antibody |
Information sourced from Uniprot.org