| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-COP9 signalosome complex subunit 1-Ser454 (420-469 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPS1 |
| Gene ID: |
2873 |
| Uniprot ID: |
CSN1_HUMAN |
| Immunogen Region: |
420-469 aa |
| Specificity: |
Phospho-CSN1 (S454) Polyclonal Antibody detects endogenous levels of CSN1 protein only when phosphorylated at S454. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human COPS1 around the phosphorylation site of Ser454 at the amino acid range 420-469 |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Protein Name | Cop9 Signalosome Complex Subunit 1Sgn1Signalosome Subunit 1G Protein Pathway Suppressor 1Gps-1Jab1-Containing Signalosome Subunit 1Protein Mfh |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 1 antibodyAnti-Sgn1 antibodyAnti-Signalosome Subunit 1 antibodyAnti-G Protein Pathway Suppressor 1 antibodyAnti-Gps-1 antibodyAnti-Jab1-Containing Signalosome Subunit 1 antibodyAnti-Protein Mfh antibodyAnti-GPS1 antibodyAnti-COPS1 antibodyAnti-CSN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
