Anti-Phospho-Gap-43-Ser41 antibody (STJA0003657)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Gap-43-Ser41 for use in WB in Mouse, Rat, Bovine, Canine, Chicken, Human, Non-Human Primates, Xenopus and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Xenopus/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Gap43 |
| Gene ID | 29423 |
| Uniprot ID | NEUM_RAT |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 conjugated to KLH. |
Additional Info
| Tissue Specificity | Expressed in hippocampal neurons, with highest levels of expression in the CA4 and CA3 neurons and lower levels in CA1 neurons. Expressed in the dorsal root ganglion. |
| Post Translational Modifications | Phosphorylated. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylated by ZDHHC3. Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. |
| Function | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. |
| Protein Name | NeuromodulinAxonal Membrane Protein Gap-43Growth-Associated Protein 43Protein F1 |
| Database Links | Reactome: R-RNO-373760 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionGrowth ConeGrowth Cone MembraneSynapseFilopodium MembranePerikaryonDendriteAxonCytoplasmCytoplasmic Surface Of Growth Cone And Synaptic Plasma Membranes |
| Alternative Antibody Names | Anti-Neuromodulin antibodyAnti-Axonal Membrane Protein Gap-43 antibodyAnti-Growth-Associated Protein 43 antibodyAnti-Protein F1 antibodyAnti-Gap43 antibody |
Information sourced from Uniprot.org