• Western blot of rat cortical lysate showing specific immunolabeling of the ~50 kDa Gap-43 protein phosphorylated at Ser41 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase ( Lambda-Ptase, 1200 units for 30 min).

Anti-Phospho-Gap-43-Ser41 antibody (STJA0003657)

SKU:
STJA0003657-100

£442.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Xenopus/Zebrafish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Gap-43-Ser41 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gap43
Gene ID: 29423
Uniprot ID: NEUM_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser41 conjugated to KLH.
Tissue Specificity Expressed in hippocampal neurons, with highest levels of expression in the CA4 and CA3 neurons and lower levels in CA1 neurons. Expressed in the dorsal root ganglion.
Post Translational Modifications Phosphorylated. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. Palmitoylated by ZDHHC3. Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
Function This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Protein Name Neuromodulin
Axonal Membrane Protein Gap-43
Growth-Associated Protein 43
Protein F1
Database Links Reactome: R-RNO-373760
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Growth Cone
Growth Cone Membrane
Synapse
Filopodium Membrane
Perikaryon
Dendrite
Axon
Cytoplasm
Cytoplasmic Surface Of Growth Cone And Synaptic Plasma Membranes
Alternative Antibody Names Anti-Neuromodulin antibody
Anti-Axonal Membrane Protein Gap-43 antibody
Anti-Growth-Associated Protein 43 antibody
Anti-Protein F1 antibody
Anti-Gap43 antibody

Information sourced from Uniprot.org

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