• Western blot of rat cortical lysate showing specific immunolabeling of the ~45 kDa GABAA Gamma 2 protein phosphorylated at Ser327 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).

Anti-Phospho-GABRG2-Ser327 antibody (STJA0003651)

SKU:
STJA0003651-100

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat/Bovine/Canine/Chicken/Human/Non-Human Primates
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-GABAA Receptor g 2-Ser327 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gabrg2
Gene ID: 29709
Uniprot ID: GBRG2_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 conjugated to KLH.
Tissue Specificity Expressed in brain (at protein level).
Post Translational Modifications Glycosylated. Palmitoylated by ZDHHC3/GODZ.required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Gamma-2
Gaba(A Receptor Subunit Gamma-2
Database Links Reactome: R-RNO-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cell Projection
Dendrite
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Gamma-2 antibody
Anti-Gaba(A Receptor Subunit Gamma-2 antibody
Anti-Gabrg2 antibody

Information sourced from Uniprot.org

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