| Tissue Specificity | Brain, heart, and skeletal muscle. |
| Post Translational Modifications | Trimethylated at Lys-165 by EEF1AKMT3. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4.trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at the N-terminus by METTL13. Mono- and dimethylated at Lys-55 by METTL13.dimethylated form is predominant. |
| Function | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. |
| Protein Name | Elongation Factor 1-Alpha 2Ef-1-Alpha-2Eukaryotic Elongation Factor 1 A-2Eef1a-2Statin-S1 |
| Database Links | Reactome: R-HSA-156842 |
| Cellular Localisation | Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Elongation Factor 1-Alpha 2 antibodyAnti-Ef-1-Alpha-2 antibodyAnti-Eukaryotic Elongation Factor 1 A-2 antibodyAnti-Eef1a-2 antibodyAnti-Statin-S1 antibodyAnti-EEF1A2 antibodyAnti-EEF1AL antibodyAnti-STN antibody |
Information sourced from Uniprot.org
