| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Dual specificity protein phosphatase 6-Ser197 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DUSP6 |
| Gene ID: |
1848 |
| Uniprot ID: |
DUS6_HUMAN |
| Specificity: |
This antibody detects endogenous levels of MKP-3 (Phospho-Ser197) at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human MKP-3 (Phospho-Ser197) |
| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibodyAnti-Dual Specificity Protein Phosphatase Pyst1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 3 antibodyAnti-Map Kinase Phosphatase 3 antibodyAnti-Mkp-3 antibodyAnti-DUSP6 antibodyAnti-MKP3 antibodyAnti-PYST1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
