| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Dual specificity protein phosphatase 1-Ser323 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUSP1 |
| Gene ID: | 1843 |
| Uniprot ID: | DUS1_HUMAN |
| Specificity: | This antibody detects endogenous levels of MKP-1 (Phospho Ser323) Rabbit pAb at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human MKP-1 (Phospho Ser323) |
| Tissue Specificity | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. |
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Protein Name | Dual Specificity Protein Phosphatase 1 Dual Specificity Protein Phosphatase Hvh1 Mitogen-Activated Protein Kinase Phosphatase 1 Map Kinase Phosphatase 1 Mkp-1 Protein-Tyrosine Phosphatase Cl100 |
| Database Links | Reactome: R-HSA-112409 Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 1 antibody Anti-Dual Specificity Protein Phosphatase Hvh1 antibody Anti-Mitogen-Activated Protein Kinase Phosphatase 1 antibody Anti-Map Kinase Phosphatase 1 antibody Anti-Mkp-1 antibody Anti-Protein-Tyrosine Phosphatase Cl100 antibody Anti-DUSP1 antibody Anti-CL100 antibody Anti-MKP1 antibody Anti-PTPN10 antibody Anti-VH1 antibody |
Information sourced from Uniprot.org