Anti-Phospho-DOK2-Tyr139 antibody (STJA0010029)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human p56 Dok-2 (Phospho Tyr139)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Docking protein 2-Tyr139 for use in IHC and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOK2 |
| Gene ID | 9046 |
| Uniprot ID | DOK2_HUMAN |
| Immunogen | Synthesized peptide derived from human p56 Dok-2 (Phospho Tyr139) |
| Specificity | This antibody detects endogenous levels of p56 Dok-2 (Phospho Tyr139) Rabbit pAb at Human, Mouse |
Additional Info
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. |
| Post Translational Modifications | On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. |
| Protein Name | Docking Protein 2Downstream Of Tyrosine Kinase 2P56(Dok-2 |
| Database Links | Reactome: R-HSA-210993Reactome: R-HSA-8853659 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Docking Protein 2 antibodyAnti-Downstream Of Tyrosine Kinase 2 antibodyAnti-P56(Dok-2 antibodyAnti-DOK2 antibody |
Information sourced from Uniprot.org