Anti-Phospho-Dishevelled 2-Ser143 antibody [R02-6I1] (STJA0034249)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser143 of human Dishevelled 2
General Information
| Short Description | Rabbit monoclonal anti-Phospho-Dishevelled 2-Ser143 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-6I1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DVL2 |
| Gene ID | 1856 |
| Uniprot ID | DVL2_HUMAN |
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser143 of human Dishevelled 2 |
Additional Info
| Post Translational Modifications | Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. Ubiquitinated via 'Lys-63'-linked polyubiquitin chains.leading to its autophagy-mediated degradation. |
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-2Dishevelled-2Dsh Homolog 2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-2028269Reactome: R-HSA-4086400Reactome: R-HSA-4608870Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5099900Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleNucleusLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their InternalizationLocalizes To Cytoplasmic PunctaInteraction With Foxk1 And Foxk2 Induces Nuclear Translocation |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-2 antibodyAnti-Dishevelled-2 antibodyAnti-Dsh Homolog 2 antibodyAnti-DVL2 antibody |
Information sourced from Uniprot.org