• Immunohistochemistry analysis of paraffin-embedded human brain, using DDR1 (Phospho-Tyr513) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from HepG2 cells treated with Na3VO4 0.3mM 40', using DDR1 (Phospho-Tyr513) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-DDR1 (Y513) Polyclonal Antibody

Anti-Phospho-DDR1-Tyr513 antibody (479-528 aa) (STJ90966)

SKU:
STJ90966

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Epithelial discoidin domain-containing receptor 1-Tyr513 (479-528 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DDR1
Gene ID: 780
Uniprot ID: DDR1_HUMAN
Immunogen Region: 479-528 aa
Specificity: Phospho-DDR1 (Y513) Polyclonal Antibody detects endogenous levels of DDR1 protein only when phosphorylated at Y513.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DDR1 around the phosphorylation site of Tyr513 at the amino acid range 479-528
Post Translational Modifications Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
Function Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Protein Name Epithelial Discoidin Domain-Containing Receptor 1
Epithelial Discoidin Domain Receptor 1
Cd167 Antigen-Like Family Member A
Cell Adhesion Kinase
Discoidin Receptor Tyrosine Kinase
Hgk2
Mammary Carcinoma Kinase 10
Mck-10
Protein-Tyrosine Kinase 3a
Protein-Tyrosine Kinase Rtk-6
Trk E
Tyrosine Kinase Ddr
Tyrosine-Protein Kinase Cak
Cd Antigen Cd167a
Database Links Reactome: R-HSA-3000171
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Isoform 3: Secreted
Isoform 4: Cell Membrane
Alternative Antibody Names Anti-Epithelial Discoidin Domain-Containing Receptor 1 antibody
Anti-Epithelial Discoidin Domain Receptor 1 antibody
Anti-Cd167 Antigen-Like Family Member A antibody
Anti-Cell Adhesion Kinase antibody
Anti-Discoidin Receptor Tyrosine Kinase antibody
Anti-Hgk2 antibody
Anti-Mammary Carcinoma Kinase 10 antibody
Anti-Mck-10 antibody
Anti-Protein-Tyrosine Kinase 3a antibody
Anti-Protein-Tyrosine Kinase Rtk-6 antibody
Anti-Trk E antibody
Anti-Tyrosine Kinase Ddr antibody
Anti-Tyrosine-Protein Kinase Cak antibody
Anti-Cd Antigen Cd167a antibody
Anti-DDR1 antibody
Anti-CAK antibody
Anti-EDDR1 antibody
Anti-NEP antibody
Anti-NTRK4 antibody
Anti-PTK3A antibody
Anti-RTK6 antibody
Anti-TRKE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance