• Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using DAPK2 (Phospho-Ser318) Antibody. The picture on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of COS7 cells, using DAPK2 (Phospho-Ser318) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-DAPK2-Ser318 antibody (284-333 aa) (STJ91302)

SKU:
STJ91302

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Death-associated protein kinase 2-Ser318 (284-333 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DAPK2
Gene ID: 23604
Uniprot ID: DAPK2_HUMAN
Immunogen Region: 284-333 aa
Specificity: Phospho-DAPK2 (S318) Polyclonal Antibody detects endogenous levels of DAPK2 protein only when phosphorylated at S318.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DAPK2 around the phosphorylation site of Ser318 at the amino acid range 284-333
Post Translational Modifications Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Protein Name Death-Associated Protein Kinase 2
Dap Kinase 2
Dap-Kinase-Related Protein 1
Drp-1
Database Links Reactome: R-HSA-418889
Cellular Localisation Cytoplasm
Cytoplasmic Vesicle
Autophagosome Lumen
Alternative Antibody Names Anti-Death-Associated Protein Kinase 2 antibody
Anti-Dap Kinase 2 antibody
Anti-Dap-Kinase-Related Protein 1 antibody
Anti-Drp-1 antibody
Anti-DAPK2 antibody

Information sourced from Uniprot.org

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